The double dipole model of theta rhythm generation: simulation of laminar field potential profiles in dorsal hippocampus of the rat.
نویسندگان
چکیده
A set of compartmental models of CA1 pyramidal, granular and polymorph cells of the dorsal hippocampus have been used to simulate membrane potentials generated by synaptic activation at various levels along these cells. From the membrane potential distributions the field potentials in dorsal CA1 and the dorsal blade of the dentate area have been simulated using a model based on volume conduction theory. Field potential profiles similar to laminar profiles, found experimentally in the dorsal hippocampus during theta rhythm, could only be simulated by assuming (almost) simultaneous synaptic excitation of the 3 cell types at given sites. The results lead to 2 alternative models for the simultaneous excitation of CA1 pyramidal cells and dentate granular cells during theta rhythm. Other electrophysiological evidence favours the model in which the two neuronal populations are activated distally near the fissure.
منابع مشابه
Dipole-like neuronal sources of theta rhythm in dorsal hippocampus, dentate gyrus and cingulate cortex of the urethane-anesthetized rat.
Spatial distribution of theta activity was investigated in the dorsal hippocampal formation and overlying neocortex of the urethane-anesthetized rat. Laminar phase profiles from semi-microelectrode penetartions showed approximately 180 degrees phase shifts combined with small amplitude values in stratum radiatum of CA1, instratum moleculare of the dentate gyrus and in layer V/VI of the cingulat...
متن کاملPii: S0149-7634(97)00014-6
LEUNG, L. S. Generation of theta and gamma rhythms in the hippocampus. NEUROSCI BIOBEHAV REV 22(2), 275–290, 1998.—In the behaving rat, theta rhythm was dominant during walking and rapid-eye-movement sleep, while irregular slow activity predominated during immobility and slow-wave sleep. Oscillatory evoked potentials of 20–50 Hz and spontaneous fast (gamma) waves were more prominent during thet...
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ورودعنوان ژورنال:
- Brain research
دوره 235 1 شماره
صفحات -
تاریخ انتشار 1982